Integrated Open Systems Unit For Sustainable Living

For Sustainable Living
Integrated Open Systems unit explores fundamental principles behind large-scale multi-layer complex systems in both biological and engineering domains. Capability to understand, design, and control such systems are essential for solving global agenda we are facing today. Among many problems, we choose to focus on biomedical and sustainability issues.

In biomedical domain, we are going to establish methodologies to understand and control multi-level physiological systems, and apply them to several real cases. We have already developed software to develop large-scale multilevel dynamical models of physiological systems (PhysioDesigner) and high-performance simulator (Flint). During next few years, we will apply our technologies to create physiologically plausible models of heart, kidney, nervous system, and circulatory system for pharmacokinetics to predict drug efficacy and side-effects. This, in term, enable us to improve and expand functionalities of our software so that it can meet requirements of complex and large-scale models. Model development process will be coupled with a high-precision in-silico prediction of drug-protein interactions which composed of an advanced molecular binding simulator elaborately developed in our unit on the structure-based system, and an integrated large-scale database with big-data driven machine learning models. It will be a one-step service package for drug developers allowing efficient predictions for drug discovery.

On sustainability front, we will continue to work with various industrial partners on Open Energy Systems (Sony CSL, Okisoukou), Electric Vehicle (PUES), and Sustainable Houses (Misawa Home), that are all integrated as an Integrated Open Energy System. Our goal is to understand design principles behind sustainable living system for tropical and subtropical areas where large numbers of people have difficulties in energy and water access yet expected to have rapid economic growth in coming decades. It is critically important to provide sustainable, resilient, yet quality living standards. We strive to investigate system architecture and design principles that can be practically deployed in the real world.

With both aspect of studies combined, we hope to contribute to global agenda issues.